They open up with Florida at AT&T Stadium that will not be an easy game. The third game of the season will be Air Force which is never easy or dealing with their offense. Add in at Penn State and back to back games at Wisconsin and home to Ohio State makes this a tough schedule. Unless the defense comes around quickly, getting to the College Football Playoffs could be tough for the Wolverines.
| Saturday Sep. 2 |  | Florida Gators AT&T Stadium, Arlington, TX | ||
| Saturday Sep. 9 |  | Cincinnati Bearcats Michigan Stadium, Ann Arbor, MI | ||
| Saturday Sep. 16 |  | Air Force Falcons Michigan Stadium, Ann Arbor, MI | ||
| Saturday Sep. 23 |  | at Purdue Boilermakers Ross-Ade Stadium, West Lafayette, IN | ||
| Saturday Sep. 30 | OFF | |||
| Saturday Oct. 7 |  | Michigan State Spartans Michigan Stadium, Ann Arbor, MI | ||
| Saturday Oct. 14 |  | at Indiana Hoosiers Memorial Stadium, Bloomington, IN | ||
| Saturday Oct. 21 |  | at Penn State Nittany Lions Beaver Stadium, University Park, PA | ||
| Saturday Oct. 28 |  | Rutgers Scarlet Knights (HC) Michigan Stadium, Ann Arbor, MI | ||
| Saturday Nov. 4 |  | Minnesota Golden Gophers Michigan Stadium, Ann Arbor, MI | ||
| Saturday Nov. 11 |  | at Maryland Terrapins Maryland Stadium, College Park, MD | ||
| Saturday Nov. 18 |  | at Wisconsin Badgers Camp Randall Stadium, Madison, WI | ||
| Saturday Nov. 25 |  | Ohio State Buckeyes Michigan Stadium, Ann Arbor, MI | ||
| Saturday Dec. 2 |  | Big Ten Championship Game Lucas Oil Stadium, Indianapolis, IN |
